San Francisco 49ers vs Las Vegas Raiders Odds, Picks & EV Data: Value on 49ers ATS
The Las Vegas Raiders are home favorites against the San Francisco 49ers in Thursday night NFL Week 3 preseason action. These West Coast rivals go to war with the Raiders as -150 home favorites and the total hovering around 38 points.
Dive into all of the 49ers vs Raiders odds and our +EV picks.
49ers vs Raiders Odds Today
| Teams | Best ML | Best Spread | Best Total |
|---|---|---|---|
| San Francisco | +150 (NoVig) | -3 (-104) 4cx | O38 (-106) Kalshi |
| Las Vegas | -153 (NoVig) | +3 (+101) Bet105 | U38 (-109) BallyBet |
Odds as of August 27, 8:19 am ET
49ers vs Raiders Analysis
Fernando Mendoza, the number one pick in the 2026 NFL Draft is expected to suit up for the Raiders as they look to build on last week’s 22-20 victory. Mendoza is 18 for 31 for 183 yards, 1 touchdown and 1 interception across his first two preseason games.
Meanwhile, back up Mac Jones will start for the 49ers following their dominant 41-17 romp over the Chargers. Jones finished 6-of-13 for 89 yards in relief of starter Brock Purdy last week.
With many of the 49ers starters, including key position players like Purdy, Christian McCaffrey, Mike Evans and Greg Kittle expected to sit, the Raiders are currently favorites. But, always keep a close eye on our odds screen to maximize your betting value as we scan over 30 sportsbooks every second.
The 49ers are 2-1-1 in their last four preseason meetings with the Raiders after winning a close 22-19 duel just last year. San Francisco is also 4-1 SU in the last five 49ers vs Raiders regular season meetings.
49ers vs Raiders +EV Opportunities Tonight
At time of writing there aren’t any +EV betting opportunities for 49ers vs Raiders, but be sure to check back throughout the day as lines move and opportunities rise.
Having said that, as seen on our smart money page, bettors are heavily leaning on the 49ers as the +3.5 underdogs. That line sits at +105 odds at time of writing, so jump on the 49ers ATS train while you can.
Remember, Mendoza threw a pick-six in limited action last week, and the third and fourth stringers on a loaded 49ers roster (who are expected to contend this season) will be chomping at the bit to make their mark in the preseason finale.